Clonality Determination by Detecting Unmodified Monoclonal Serum Free Light Chains Using On-Probe Extraction Coupled with Liquid Chromatography-High-Resolution Mass Spectrometry
DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models
08/2024 Journal: Journal of Translational Medicine Author: Lin, S., Zhang, Y., Yao, J., et al.
Discovery of novel dihydropyrrolidone-thiadiazole compound crosstalk between the YycG/F two-component regulatory pathway and cell membrane homeostasis to combat methicillin-resistant Staphylococcus aureus
11/2024 Journal: European Journal of Medicinal Chemistry Author: Xiong, Y., Wang, R., Zheng, J., et al.
Tumor targeting in situ aggregation of nanoparticle-to-nanoparticle strategy to simultaneously induce ferroptosis and immunogenic cell death using complementary heparin and protamine molecules
Design and development of novel self-assembled catechol-modified bile acid conjugates as pH-responsive apical sodium-dependent bile acid transporter targeting nanoparticles
07/2024 Journal: Biomaterials Author: Lee, D., Yang, S., Kweon, S., et al.
Baohuoside I inhibits virulence of multidrug-resistant Staphylococcus aureus by targeting the transcription Staphylococcus accessory regulator factor SarZ
Monovalent Omicron COVID-19 vaccine triggers superior neutralizing antibody responses against Omicron subvariants than Delta and Omicron bivalent vaccine.
10/2023 Journal: Human Vaccines & Immunotherapeutics Author: Li, W., Zhao, T., Tao, B., et al.
IMM47, a humanized monoclonal antibody that targets CD24, exhibits exceptional anti-tumor efficacy by blocking the CD24/Siglec-10 interaction and can be used as monotherapy or in combination with anti-PD1 antibodies for cancer immunotherapy
09/2023 Journal: Antibody Therapeutics Author: Li, S., Chen, D., Guo, H., et al.
Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody
07/2022 Journal: PLOS PATHOGENS Author: Piepenbrink, M., Park, J., Deshpande, A., et al.
Microprobe-Capture In-Emitter Elution: An Affinity Capture Technique to Directly Couple a Label-Free Optical Sensing Technology with Mass Spectrometry for Protein Analysis
03/2023 Journal: Analytical Chemistry Author: Luo, R., Yang, S., et al.
Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range
04/2023 Journal: PLOS PATHOGENS Author: Ni, D., Turelli, P., Beckert, B., et al
A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape
05/2022 Journal: Small Method Author: Feng, B., Chen, Z., Sun, J., et al.