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Baohuoside I inhibits virulence of multidrug-resistant Staphylococcus aureus by targeting the transcription Staphylococcus accessory regulator factor SarZ

04/2024 Journal: Phytomedicine Author: Wen, Z., Chen, C., Shang, Y., et al.

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Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein

02/2024 Journal: nature communications Author: Mannar, D., Saville, J., Poloni, C., et al.

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AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria

02/2024 Journal: Emerging Microbes & Infections Author: Zheng, J., Liu, X., Xiong, Y., et al.

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The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

02/2024 Journal: nature Author: Xu, P., Liu, Y., Liu, C., et al.

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Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus

02/2024 Journal: nature communications Author: Garrison, A., Moresco, V., Zeng, X., et al.

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The subgenomic flaviviral RNA suppresses RNA interference through competing with siRNAs for binding RISC components

01/2024 Journal: JOURNAL OF VIROLOGY Author: Chen, X., Li, R., Chen, R., et al.

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The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruse

01/2024 Journal: nature communications Author: Ma, H., Adams, L., Raju, S., et al.

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SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode

12/2023 Journal: communications biology Author: Goike, J., Hsieh, C., Horton, A., et al.

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Specific binding of plant-expressed anti-PD-L1 monoclonal antibody to multiple myeloma cell line RPMI8226

11/2023 Journal: Plant Biotechnology Reports Author: Jin, C., Lee, C., Hwang, H., et al.

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A Potent Recombinant Polyclonal Antibody Therapeutic for Protection Against New Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern

04/2023 Journal: The Journal of Infectious Diseases Author: Wayham, N., Niedecken, A., Simons, J., et al.

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Effects of Covalent or Noncovalent Binding of Different Polyphenols to Acid-Soluble Collagen on Protein Structure, Functionality, and Digestibility

11/2023 Journal: JOURNAL OF AGRICULTURAL AND FOOD HEMISTRY Author: Wang, Y., Zhou, J., Tian, X., et al.

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Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus

01/2024 Journal: Cell Author: Adams, L., Raju, S., Ma, H., et al.

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TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons

11/2023 Journal: Nature Author: Zhao, S., Lu, J., Pan, B., et al.

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Structure-function analysis of tight junction-directed permeation enhancer PIP250

11/2023 Journal: Journal of Controlled Release Author: Taverner, A., Almansour, K., Gridley, K., et al.

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Monovalent Omicron COVID-19 vaccine triggers superior neutralizing antibody responses against Omicron subvariants than Delta and Omicron bivalent vaccine.

10/2023 Journal: Human Vaccines & Immunotherapeutics Author: Li, W., Zhao, T., Tao, B., et al.

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Global profiling of ribosomal protein acetylation reveals essentiality of acetylation homeostasis in maintaining ribosome assembly and function

09/2023 Journal: Nucleic Acids Research Author: Ni, J., Li, S., Lai, Y., et al.

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Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8

10/2023 Journal: Cell Author: Zimmerman, O., Zimmerman, M., Raju, S., et al.

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Elucidating the development, characterization, and antitumor potential of a novel humanized antibody against Trop2

09/2023 Journal: International Journal of Biological Macromolecules Author: Zhou, D., Sun, L., Yu, Q., et al.

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IMM47, a humanized monoclonal antibody that targets CD24, exhibits exceptional anti-tumor efficacy by blocking the CD24/Siglec-10 interaction and can be used as monotherapy or in combination with anti-PD1 antibodies for cancer immunotherapy

09/2023 Journal: Antibody Therapeutics Author: Li, S., Chen, D., Guo, H., et al.

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Study of β1-transferrin and β2-transferrin using microprobe-capture in-emitter elution and high-resolution mass spectrometry

09/2023 Journal: scientific reports Author: Luo, R., Pfaffroth, C., Yang, S., et al.

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A Potential Antibody–Drug Conjugate Targeting Human LIV1 for the Treatment of Triple-Negative Breast Cancer

08/2023 Journal: Thieme Author: Zhang, W., Liu, H., Zhuang, W., et al.

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Broad-spectrum humanized monoclonal neutralizing antibody against SARS-CoV-2 variants, including the Omicron variant

08/2023 Journal: Frontiers in Cellular and Infectiction Author: Wen, K., Cai, J., Fan, X., et al.

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Real-time bio-layer interferometry ubiquitination assays as alternatives to western blotting

10/2023 Journal: Analytical Biochemistry Author: De Silva, A., Shrestha, S., Page, R., et al.

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Sustained Delivery of the Antiviral Protein Griffithsin and Its Adhesion to a Biological Surface by a Silk Fibroin Scaffold

08/2023 Journal: Materials Author: Guan, W., Zhang, N., Bains, A., et al.

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Self-play reinforcement learning guides protein engineering

07/2023 Journal: nature machine intelligence Author: Wang, Y., Tang, H., Huang, L., et al.

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Risk Assessment of the Possible Intermediate Host Role of Pigs for Coronaviruses with a Deep Learning Predictor

07/2023 Journal: viruses Author: Jiang, S., Zhang, S., Kang, X., et al.

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Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

05/2023 Journal: ACS Chemical Biology Author: Marchand, A., Bonati, L., Shui, S., et al.

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DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice

04/2023 Journal: Genes & Diseases Author: Chai, D., Wang, X., Neeli, P., et al.

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Moderate-Affinity Affibodies Modulate the Delivery and Bioactivity of Bone Morphogenetic Protein-2

06/2023 Journal: Advanced Healthcare Materials Author: Dorogin, J., Hochstatter, H., Shepherd, S., et al.

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Structure-based virtual screening identifies small-molecule inhibitors of O-fucosyltransferase SPINDLY in Arabidopsis

10/2023 Journal: THE PLANT CELL Author: Aizezi, Y., Zhao, H., Zhang, Z., et al.

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A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapy

10/2023 Journal: Plos one Author: Dower, W., Angie Inkyung Park, Bakker, A., et al.

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IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation

05/2023 Journal: mAbs Author: Dowling, J., Nikitin, P., Shen, F., et al.

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Characterization of the SARS-CoV-2 BA.5.5 and BQ.1.1 Omicron variants in mice and hamsters

09/2023 Journal: journal of virology Author: Case, J., Conceptualization, Data curation, et al.

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De novo design of protein interactions with learned surface fingerprints

04/2023 Journal: Nature Author: Gainza, P., Wehrle, S., Hall-Beauvais, A., et al.

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Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors

01/2024 Journal: cell reports medicine Author: Wang, Y., Sun, Y., Deng, S., et al.

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A general computational design strategy for stabilizing viral class I fusion proteins

02/2024 Journal: Nature communications Author: Gonzalez, K., Huang, J., Criado, M., et al.

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Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

01/2023 Journal: nature communication Author: Tan, C., Trew, J., Peacock, T., et al.

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Rewiring Cancer Drivers to Activate Apoptosis

07/2023 Journal: nature Author: Gourisankar, S., Krokhotin, A., Ji, W., et al.

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An RBD virus-like particle vaccine for SARS-CoV-2 induces cross-variant antibody responses in mice and macaques

04/2023 Journal: Signal Transduction and Targeted Therapy Author: Li, Y., Zhang, Y., Zhou, Y., et al.

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Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody

07/2022 Journal: PLOS PATHOGENS Author: Piepenbrink, M., Park, J., Deshpande, A., et al.

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Structural and functional characterization of capsid binding by anti-AAV9 monoclonal antibodies from infants after SMA gene therapy

04/2023 Journal: Molecular Therapy Author: Logan, G., Mietzsch, M., Khandekar, N., et al.

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Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants

04/2023 Journal: communications biology Author: Guo, H., Yang, Y., Zhao, T., et al.

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Microprobe-Capture In-Emitter Elution: An Affinity Capture Technique to Directly Couple a Label-Free Optical Sensing Technology with Mass Spectrometry for Protein Analysis

03/2023 Journal: Analytical Chemistry Author: Luo, R., Yang, S., et al.

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Human bocavirus 1 and 2 genotype-specific antibodies for rapid antigen testing in pediatric patients with acute respiratory infections

02/2023 Journal: World Journal of Pediatrics Author: De, R., Xu, Y., Wang, F., et al.

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Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin

02/2023 Journal: Pharmaceutics Author: Zhu, Y., Sysoev, A., et al.

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Peptide probes with high affinity to target protein selection by phage display and characterization using biophysical approaches

05/2022 Journal: New Journal of Chemistry Author: Yany, X., Bai, L., Chen, Y., et al.

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Discovery of allosteric SHP2 inhibitors through ensemble-based consensus molecular docking, endpoint and absolute binding free energy calculations

01/2023 Journal: Computers in Biology and Medicine Author: Jama, M., Ahmed, M., Jutla, A., et al.

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Rice black-streaked dwarf virus P10 promotes phosphorylation of GAPDH (glyceraldehyde-3-phosphate dehydrogenase) to induce autophagy in Laodelphax striatellus

07/2021 Journal: Autophagy Author: Wany, Q., Lu, L., Zeng, M., et al.

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G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes

12/2022 Journal: Genome Biology Author: Li, C., Yin, Z., Xiao, R., et al.

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A potent, broadly protective vaccine against SARS-CoV-2 variants of concern

11/2022 Journal: npj Vaccines Author: Wany, Z., An, J., Liu, K., et al.

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Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus

11/2022 Journal: nature communications Author: Durie, I., Tehrani, Z., Karaaslan, E., et al.

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Preparation of the luciferase-labeled antibody for improving the detection sensitivity of viral antigen

07/2022 Journal: Virology Journal Author: Tany, Y., Li, Y., Zhang, S., et al.

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Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy

07/2022 Journal: Nature Communications Author: Prahl, M., Golan, Y., Cassidy, A., et al.

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Graphene oxide-based plasma membrane-philic delivery platform to generate tolerogenic dendritic cells in GVHD immunotherapy

10/2022 Journal: nanotoday Author: Sun, S., He, C., Li, C., et al.

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Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination

04/2022 Journal: Signal Transduction and Targeted Therapy Author: Chi, X., Guo, Y., et al.

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Clathrin-associated AP-1 controls termination of STING singalling

10/2022 Journal: Nature Author: Liu, Y., Xu, P., Rivara, S., et al

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SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope

09/2022 Journal: Nature Microbiological Author: He, P., Liu, B., Gao, X., et al

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Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases

09/2022 Journal: Nature Communication Author: Sun, X., Yuang, Y., Chen, Q., et al

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Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

04/2023 Journal: PLOS PATHOGENS Author: Ni, D., Turelli, P., Beckert, B., et al

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Theranostic application of 64Cu/177Lu-labeled anti-Trop2 monoclonal antibody in pancreatic cancer tumor models

08/2022 Journal: European Journal of Nuclear Medicine and Molecular Imaging Author: Li, C., Liu, J., Yang, X., et al

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PI(4,5)P2-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt–β-catenin signaling

07/2022 Journal: ScienceSignaling Author: Mahoney, J., Bruguera, E., Vasishtha, M., et al.

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Tumor necrosis factor alpha delivers exogenous inflammation-related microRNAs to recipient cells with functional targeting capabilities

07/2022 Journal: Molecular Therapy Author: Zhao, Y., Zhang, T., Shen, X., et al.

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Breaking the Status Quo of Characterization with Biolayer Interferometry

06/2022 Magazine: LifeScience Review

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A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape

05/2022 Journal: Small Method Author: Feng, B., Chen, Z., Sun, J., et al.

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An automated, rapid fluorescent immunoassay to quantify serum soluble programmed death-1 (PD-1) protein using testing-on-a-probe biosensors

05/2022 Journal: Clinical Chemistry and Laboratory Medicine Author: Zhang, J., Chen, L., Xu, Q., et al.

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Development of a rapid neutralizing antibody test for SARS-CoV-2 and its application for neutralizing antibody screening and vaccinated serum testing

04/2022 Journal: Infectious Medicine Author: Li, Y., Wang, M., Wu, H., et al.

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Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

04/2022 Journal: Cell Author: Li, C., Zhan, W., Yang, Z., et al.

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Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters

04/2022 Journal: Nature Author: Deng, YQ., Zhang, N., Zhang, Y., et al.

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Measurements of SARS-CoV-2 antibody dissociation rate constant by chaotrope-free biolayer interferometry in serum of COVID-19 convalescent patients

03/2022 Journal: Biosensors and Bioelectronics Author: Hao, Y., Yang, H., Karbaschi, M., et al.

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First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variants

03/2022 Journal: Clinica Chimica Author: Titong, A., Gallolu Kankanamalage, S., Dong, J. et al.

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Reconstitution of purified membrane protein dimers in lipid nanodiscs with defined stoichiometry and orientation using a split GFP tether

01/2022 Journal: JBC Author: Bruguera, E., Mahoney, J., Weis, W., et al.

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Development of recombinant COVID-19 vaccine based on CHO-producted, prefusion spike trimer and alum/CpG adjuvants

10/2021 Journal: Vaccine Author: Liu, H., Zhou, C., An, J., et al.

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Predicting Mutational Effects on Receptor Binding of the Spike Protein of SARS-CoV-2 Variants

10/2021 Journal: Journal of the American Chemical Society Author: Bai, C., Wang, J., Chen, G., et al.

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Generation and Characterization of a Nanobody Against SARS-CoV

09/2021 Journal: Virologica Sinica Author: Li, JF., He, L., Deng, YQ. et al.

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TOP-Plus is a Versatile Biosensor Platform for Monitoring SARS-CoV-2 Antibody Durability

09/2021 Journal: Clinical Chemistry Author: Racine-Brzostek, S., Karbaschi, M., Gaebler, C., et al.

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Surface Ligand Valency and Immunoliposome Binding: when More Is Not Always Better

08/2021 Journal: Pharm Res Author: Li, H., Di, J., Peng, B. et al.

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Lack of blocking activity in anti-CTLA-4 antibodies reduces toxicity, but not anti-tumor efficacy

07/2021 Journal: bioRxiv Author: Stone, E., Carter, K., Wagner, E., et al.

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Potent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccination

06/2021 Journal: Emerging Microbes & Infections Author: Chen, Y., Zhu, L., Huang, W., et al.

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Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients

05/2021 Journal: Virologica Sinica Author: Li, J., He, L., Deng, Y., et al.

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A SARS-CoV-2 Label-Free Surrogate Virus Neutralization Test and a Longitudinal Study of Antibody Characteristics in COVID-19 Patients

04/2021 Journal: JCM Author: Luo, R., Yun, C., Chakraborty, I., et al.

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Development of humanized tri-specific nanobodies with potent neutralization for SARS-CoV-2

10/2020 Journal: Scientific Reports Author: Dong, J., Huang, B., Wang, B., et al.

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A potent SARS-CoV-2 neutralizing human monoclonal antibody that reduces viral burden and disease severity in Syrian hamsters

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Selection and characterization of an ssDNA aptamer against thyroglobulin

09/2020 Journal: Talanta Author: Zhu, C., Li, L., Fang, S., et al.

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Kinetics of SARS-CoV-2 Antibody Avidity maturation and association with disease severity

09/2020 Journal: Clinical Infectious Diseases Author: Luo, R., Chakraborty, I., Yun, C., et al.

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Development of Label-Free Immunoassays as Novel Solutions for the measurement of monoclonal antibody drugs and antidrug antibodies

07/2020 Journal: Clinical Chemistry Author: Luo, R., Chakraborty, I., Lazar-Molnar, E., et al.

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A thin-film interferometry-based label-free immunoassay for the detection of daratumumab interference in serum protein electrophoresis

12/2019 Journal: Clinica Chimica Author: Luo, R., Chakraborty, I., Zuk, R., et al.